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Despite the lack of official approval, both compounds have accumulated substantial preclinical evidence and extensive anecdotal reports from users worldwide

A major mechanism linking GSH to signal regulation is S-glutathionylation (SSG), a reversible post-translational modification in which GSH forms a mixed disulfide bond with reactive cysteine residues on target proteins

GST-M1*0F requencies range from 42-60% in Caucasians [111] and GST-M1*0 appears to be associated with social behavioural changes in mice compared to wild type [112]

Proposed mechanisms include upregulation of growth factor receptors, stimulation of fibroblast migration and collagen synthesis, and promotion of angiogenesis at injury sites

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